PEPTIDOGLICANO Mureina . Longitudinal and three-dimensional layers of the bacteria that make up the cell wall of them, and covering the plasma membrane. They are made up of a part of peptides and lipid part, which replaces the cholesterol of cells. They are up to 40 layers in the case of Gram positives and constitute a single and thin in the case of Gram negatives. Peptidoglycans are important because they help defend the bacteria from osmotic pressure, which if it did not exist would destroy them. There are other bacteria that do not have a cell wall and that resolve this by increasing the rigidity of the plasma membrane with sterols.