granddaughter (from lat. vg. nepta , granddaughter) 1 n. Regarding a person, son or daughter of a son or daughter of theirs. 2 Descendant of any degree from the third generation. Bichozno, great-grandson, great-grandson, chozno, quadriplegic, grand-grandson, grand-grandson, great-great-grandson, trans-grandchild. Grandfather. Relative.