He syndrome XXXXX (also called pentasomia X or 49) is an alteration of the chromosomes X present normally in the woman. Instead of having two has five X chromosomes. Is a feature very rare, since only is has knowledge of some 25 cases in the world.It was discovered in 1963 and is associated with microcephaly (small head), micrognathia (small jaw) and round face. The ears are usually low and malformed, them eyes very separate and exorbitant, the nose with the bridge nasal depressed and wide, the mouth with fissure in the palate highly arched, teeth abnormal and lips wrinkled and thick. The neck is short and without movement, the hands and feet are small.