As an acronym does not have much use in Spanish, the /U/ in many cases is for "University" ("University of Palermo", "Public University", . . . ) or more rarely by "Union" or "Unity" ("Popular Unity"). In English it appears more as an acronym for the companies Universal Pictures (cinematographic), United Press (journalism), Union Pacific (railway), . . . and also as a way to abbreviate user profile, urban population, or unit price. But the most curious (and erroneous) use is that of 'uP' as a "microprocessor", where someone saw a resemblance between the Latin /u/ and the micro symbol; ( micro ) , or even with the Greek letter mu; (mu) which is the one used as a replacement, and he put it in because it was comfortable on the keyboard.
UP acronym for Popular Unity coalition formed by the Chilean Socialist Party and Communist Party in 1969 and which came to power in 1970 with Salvador Allende. He tried to bring socialism to power by democratic means, but soon he moved away from the laws and the current constitution, being declared non-compliant with it by the Chamber of Deputies, the Comptroller's Office and the Supreme Court. His disastrous program of nationalizations and expropriations led the country to total ruin in less than 1000 days. When a civil war was brewing, the armed forces seized power and Augusto Pinochet took over, disappearing this calamitous alliance.