TOF in aeronautics, is short for Time of flight, which means flight time. In medicine it is the abbreviation of file:tetralogy of Fallot (TOF). Tetralogy of Fallot (TOF) is a cardiac anomaly in children, which refers to a combination of four related heart defects that commonly occur together. The four defects are: defect in the ventricular septum (acronym in English VSD), pulmonary stenosis, upper Aorta and right ventricular hypertrophy.