It is a male name of Latin origin. It means Holy (derived from Sanctius or Sanctinus). Of Great Holiness. It is a common male name in Italy. Name of a fashion designer named Santino Rice. Santino Marella is a professional wrestler. Santino Fontana an actor. Name of restaurant and pizzeria in Mexico D . F. Name of Vitto Corleone's eldest son, nicknamed "Sonny" and fictional character in the movie "The Godfather".